Selectively reduced posterior corpus callosum size in a population-based sample of young adults born with low birth weight.

Research Area: Research Year: 2011
Type of Publication: Article
Authors: Aukland, S. M.; Westerhausen, Rene; von Plessen, Kerstin; Odberg, M. D.; Elgen, I. B.; Peterson, B. S.; Ersland, Lars; Eide, G. E.; Rosendahl, K.
Abstract:
BACKGROUND AND PURPOSE: Several studies suggest that VLBW is associated with a reduced CC size later in life. We aimed to clarify this in a prospective, controlled study of 19-year-olds, hypothesizing that those with LBWs had smaller subregions of CC than the age-matched controls, even after correcting for brain volume. MATERIALS AND METHODS: One hundred thirteen survivors of LBW (BW W compared with controls, even after adjusting for size of the forebrain. Individuals who were born with a LBW had a smaller CC (mean area, 553.4 mm(2)) than the controls (mean area, 584.1 mm(2)). Differences in total area, however, did not remain statistically significant after adjusting for FBV. CONCLUSIONS: The uncorrected callosal size in 19-years-olds born with LBW was smaller than that of normal controls. However, after adjusting for FBV, the group difference was restricted to the posterior third. The clinical impact of a smaller posterior part needs further investigation.
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