Age Related Cognitive Changes and Subcortical Structural

Research Area: Research Year: 2010
Type of Publication: Poster presentation
Authors: Ystad, Martin; Hodneland, Erland; Adolfsdottir, Steinunn; Lundervold, Astri J; Eichele, Tom; Lundervold, Arvid
Age related cognitive decline is associated with changes in functional connectivity between cortical resting state networks (RSNs) [1]. Furthermore, white matter "disconnection" has been suggested as a fundamental mechanism for cognitive decline in aging [2]. The thalamus and basal ganglia are structurally connected to the entire cortex, and changes in their functional connectivities to cortical RSNs have recently been found to be associated with age related cognitive decline [3]. As functional connectivity has been shown to rely on underlying structural connectivity [4], we hypothesize that white matter integrity, measured as fractional anisotropy (FA), in fibers connecting the subcortical nuclei to cortical RSNs are associated with cognitive function in healthy elderly.