MR spectroscopy (MRS)

Magnetic Resonance Spectroscopy (MRS) is a non-invasive technique that provides information about brain metabolism through tissue characterization on a biochemical level. MRS information is most commonly based the hydrogen proton nucleus, and can be acquired either in a single- or multivoxel way. MRS allows for quantification of brain tissue metabolites, such as NAA, Lactate, Alanine, Glutamate/Glutamine, and others. MRS spectra are dependent on the MR scanner field strength with higher field strengths allowing for improved signal quantification. MRS can be used to identify brain abnormality in both neurological and psychiatric disorders.


The figure shows the metabolite spectrum acquired from a GE Signa 3.0T scanner from a single voxel located in the medial frontal cortex, including the anterior cingulate.